Life Events: Death of a loved one, divorce, job loss, financial crisis, etc. can lead to depression.
Biological Factors: Changes in the levels of chemicals in the brain (neurotransmitters – for example, serotonin and dopamine) cause depression.
Genetics: If someone in your family has depression, you are more likely to get it.
Hormonal Changes: Hormonal changes that occur in women before menstruation and after childbirth (postpartum depression) can cause depression.
Chronic Diseases: People with chronic diseases such as cancer, heart disease, and diabetes are more likely to get depression.
Side Effects of Medications: Taking certain medications can affect mood and lead to depression.
Alcohol and drugs: Excessive use of these affects brain function and increases depression.