Creatinine is a waste product produced by muscle activity in the body. Healthy kidneys filter it from the blood and excrete it through urine. If creatinine levels are high in a blood test, it means that the kidneys are not functioning properly. The main causes are:
Uncontrolled diabetes: The most important cause of kidney failure is high blood sugar levels. If sugar is not controlled for a long time, it damages the delicate blood vessels in the kidneys and reduces their ability to filter waste.
High blood pressure (High BP): When blood pressure increases, the blood vessels to the kidneys thicken or narrow. This reduces blood flow to the kidneys and prevents the excretion of creatinine.
Kidney infections and stones: Infections in the kidneys (Pyelonephritis) can cause cell damage. Additionally, stones in the kidney or urinary tract can cause urinary obstruction, which puts pressure on the kidneys and increases creatinine levels.
Overuse of medications: Taking painkillers (NSAIDs) for a long time without a doctor’s prescription can directly affect the kidneys. Some antibiotics and heart disease medications can also put strain on the kidneys.
Dehydration: Not drinking enough water reduces blood volume and affects blood flow to the kidneys. This can temporarily cause creatinine levels to rise.
